The left-hander, known for a crisp fastball, a slider and his signature changeup, thrived on pitches that ranged from 80 to 89 mph. He got 14 of his 21 outs on those pitches.
In holding the Marlins to two runs over seven innings, Santana struck out four straight batters at one stage. One came on an offspeed pitch, while the others were between 90 and 92 mph.
On his slowest pitch of the game, the 76-mph changeup to Marlins outfielder Josh Willingham, Santana's no-hitter was broken up by a home run estimated to travel 369 feet.
Perhaps Santana's most important pitch of the game came in the fifth inning, when the Marlins had runners on first and second with two outs and the dangerous Hanley Ramirez batting. Santana struck him out on a 90-mph fastball.
Charlie Nobles is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.