In the first inning, the Nationals used the long ball to score five runs against Mets right-hander Matt Harvey. Ian Desmond led off with a home run. After Ryan Zimmerman hit an RBI double, Jayson Werth hit a monster two-run homer to give Washington a 4-0 lead. Two batters later, Roger Bernadina hit a solo homer.
Stephen Strasburg started for Washington and had another solid outing. He pitched five scoreless innings, allowed five hits, struck out five and walked one. The Nationals' Opening Day starter threw 84 pitches, 46 for strikes. Ruben Tejada was the only Mets player able to collect at least two hits against Strasburg.
In the second inning, Washington added three more runs off Justin Hampson. Danny Espinosa came home on a bases-loaded walk to Bernadina, while Mark DeRosa and Jesus Flores scored on a throwing error by catcher Lucas May.
In the next inning, with Hampson still on the mound, DeRosa and Bernadina added RBI singles. In the fifth, Mets right-hander Manny Acosta allowed a single to Bernadina, scoring Zimmerman. Bernadina ended up with four RBIs in the game.
Mets outfielder Jason Bay exited with a bruised right forearm after being hit by a pitch from Strasburg in the third inning.
Up next: Johan Santana should increase his workload to around 90 pitches in his fifth Grapefruit League start, Monday at 1:05 p.m. ET against the Cardinals at Jupiter, Fla. Santana has two starts remaining before his Opening Day assignment April 5 against the Braves, though his final outing could come in a Minor League game.
Bill Ladson is a reporter for MLB.com and writes an MLBlog, All Nats All the time. He also could be found on Twitter @WashingNats. This story was not subject to the approval of Major League Baseball or its clubs.