The start will be Santana's first since he was placed on the disabled list on July 21 with a sprained right ankle. He threw three scoreless innings and three simulated innings in the bullpen with Class A Brooklyn on Sunday.
"I'm very, very confident that Saturday night we're going to see a good outing out of Johan, because he's feeling so much better about the way his arm feels, the way his leg feels and the energy he's gotten back," Collins said. "But we can be very cautious with him during the month of September to make sure he goes into the offseason feeling good."
Collins said to not be surprised if he opts to give Santana extra rest on a regular basis in September to ensure he finishes the year strong.
"I don't want to go into next Spring Training trying to find if Johan Santana is going to be healthy again," Collins said. "I want to know he is."